研究人员确定了儿童败血症风险的预测因素

昆士兰大学的研究人员发现了儿童败血症的预测因子。通过分析 900 多名危重儿童的血液样本，他们可以在 24 小时内预测哪些儿童有患败血症和随后器官衰竭的风险。这一发现意义重大，因为脓毒症的早期发现对于挽救生命至关重要，使临床医生能够及时采取干预措施。

Can We Predict Sepsis in Kids?

我们可以预测儿童败血症吗？

Researchers at the University of Queensland have devised a way to predict whether a child is at risk of developing sepsis and subsequent organ failure.

昆士兰大学的研究人员设计了一种方法来预测儿童是否有患败血症和随后的器官衰竭的风险。

How Did They Do It?

他们是如何做到的呢？

"We analyzed blood samples from over 900 critically ill kids," explains Dr. Lachlan Coin, an associate professor at UQ's Institute for Molecular Bioscience. "By studying gene expression patterns, we could identify who would develop organ failure within 24 hours."

“我们分析了 900 多名危重儿童的血液样本，”昆士兰大学分子生物科学研究所副教授 Lachlan Coin 博士解释道。 “通过研究基因表达模式，我们可以确定谁会在 24 小时内出现器官衰竭。”

What's the Significance?

有什么意义？

"Sepsis is a life-threatening condition," says Professor Luregn Schlapbach from UQ's Child Health Research Centre. "Early detection is crucial, and this discovery could empower clinicians."

“败血症是一种危及生命的疾病，”昆士兰大学儿童健康研究中心的 Luregn Schlapbach 教授说。 “早期发现至关重要，这一发现可以为临床医生提供帮助。”

Why Is It So Tricky to Diagnose Sepsis?

为什么诊断脓毒症如此困难？

"Many childhood illnesses mimic sepsis," Professor Schlapbach explains. "Without specific markers, it's hard to tell who's at risk."

“许多儿童疾病类似于败血症，”施拉巴赫教授解释道。 “如果没有特定的标记，很难判断谁面临风险。”

What's the Current Treatment Approach?

目前的治疗方法是什么？

"If sepsis is suspected, doctors give antibiotics, fluids, and increased observation," says Professor Schlapbach. "But this approach can lead to unnecessary treatment."

“如果怀疑败血症，医生会给予抗生素、液体并加强观察，”施拉巴赫教授说。 “但这种方法可能会导致不必要的治疗。”

What's Next?

下一步是什么？

"We need more research before we can implement this discovery in clinical practice," Professor Schlapbach says. "Our goal is to develop a point-of-care platform that can generate results from a blood test within an hour."

“我们需要更多的研究才能将这一发现应用于临床实践，”施拉巴赫教授说。 “我们的目标是开发一个可以在一小时内生成血液检测结果的即时护理平台。”

Who's Behind the Research?

谁是这项研究的幕后推手？

This study was funded by various organizations, including the Australian Government Medical Research Future Fund and the Children's Hospital Foundation Queensland. Dr. Coin also holds a professorship at the Doherty Institute at the University of Melbourne.

这项研究由多个组织资助，包括澳大利亚政府医学研究未来基金和昆士兰儿童医院基金会。 Coin 博士还担任墨尔本大学多尔蒂研究所的教授职位。

Where Can I Find the Study?

在哪里可以找到该研究？

The research paper was published in the journal Lancet Child and Adolescent Health.

该研究论文发表在《柳叶刀儿童与青少年健康》杂志上。

Media Contact

媒体联系

For media inquiries, contact the UQ Faculty of Medicine Communications team at med.media@uq.edu.au or +61 436 368 746.

如需媒体咨询，请联系昆士兰大学医学院传播团队：med.media@uq.edu.au 或 +61 436 368 746。