晶片技術有望取代離心機以實現卓越的血漿分離

ExoArc 是一款創新設備，透過一步有效去除 99.9% 以上的血球和血小板，徹底改變了血漿分離，為生物標記分析和奈米顆粒分離提供高純度血漿。該技術為傳統離心方法提供了更快、更精確的替代方案，能夠快速臨床診斷癌症等疾病，並改善糖尿病等慢性病的個人化醫療。

Can a Chip Replace the Centrifuge for Blood Plasma Isolation?

晶片可以替代離心機進行血漿分離嗎？

The ExoArc device has emerged as a potential game-changer in blood plasma isolation, promising high-quality plasma with exceptional purity. Unlike traditional centrifuges, which rely on spinning blood samples to separate plasma, ExoArc utilizes a microfluidic chip to achieve a more precise and efficient separation process.

ExoArc 設備已成為血漿分離領域潛在的遊戲規則改變者，並有望提供具有卓越純度的高品質血漿。與傳統離心機依靠旋轉血液樣本來分離血漿不同，ExoArc 利用微流控晶片實現更精確、更有效率的分離過程。

How Does ExoArc Achieve Such High Purity?

ExoArc 如何達到如此高的純度？

ExoArc's microfluidic chip leverages unique flow dynamics within tiny channels to separate biological materials based on size. By precisely controlling the flow rates and channel dimensions, the chip effectively removes over 99.9% of blood cells and platelets in a single step. This high level of purity ensures minimal contamination from degraded cellular material, which can lead to inaccurate diagnostic tests.

ExoArc 的微流控晶片利用微小通道內獨特的流動動力學來根據尺寸分離生物材料。透過精確控制流速和通道尺寸，該晶片可一步有效去除 99.9% 以上的血球和血小板。這種高純度確保了降解細胞材料的污染最小化，這種污染可能導致診斷測試不準確。

Clinical Validation: Accurate Cancer Diagnosis

臨床驗證：準確的癌症診斷

In collaboration with clinicians from the National Cancer Center Singapore (NCCS) and other medical institutions, ExoArc's performance was clinically validated. The device successfully diagnosed non-small cell lung cancer with a sensitivity of 90% by analyzing the microRNA profile of blood plasma. This demonstrates ExoArc's potential for early and accurate cancer detection.

ExoArc 與新加坡國家癌症中心 (NCCS) 和其他醫療機構的臨床醫生合作，其表現得到了臨床驗證。該設備透過分析血漿的 microRNA 譜，成功診斷出非小細胞肺癌，靈敏度高達 90%。這證明了 ExoArc 在早期、準確的癌症檢測方面的潛力。

Beyond Cancer: Applications in Diabetes Research

超越癌症：在糖尿病研究中的應用

ExoArc's versatility extends beyond cancer diagnosis. The team also demonstrated its utility in studying microRNA molecules from blood plasma samples of individuals with type 2 diabetes mellitus. By identifying 293 different microRNA molecules, the research suggests ExoArc's potential for isolating and identifying disease-related biomarkers in a wide range of conditions.

ExoArc 的多功能性超出了癌症診斷的範圍。該團隊還展示了其在研究 2 型糖尿病患者血漿樣本中的 microRNA 分子方面的實用性。透過識別 293 種不同的 microRNA 分子，該研究表明 ExoArc 在多種條件下分離和識別疾病相關生物標記的潛力。

Benefits for Patients and Clinicians

對病人和臨床醫生的好處

ExoArc offers several advantages over conventional centrifuges. Its automated and rapid isolation process significantly reduces waiting time for test results, alleviating patient anxiety. Additionally, the high-quality plasma obtained through ExoArc enables more accurate diagnostic tests, leading to improved patient care.

與傳統離心機相比，ExoArc 具有多種優勢。其自動化、快速的隔離過程顯著減少了檢測結果的等待時間，減輕了患者的焦慮。此外，透過 ExoArc 獲得的高品質血漿可以實現更準確的診斷測試，從而改善患者護理。

Scaling Up for Clinical Implementation

擴大臨床實施規模

ExoArc's modular design allows for scaling up by incorporating multiple channels. This feature enables simultaneous isolation of blood plasma from multiple samples, increasing throughput and reducing processing time. Automation of the process further streamlines the diagnostic workflow and potentially reduces overall costs.

ExoArc 的模組化設計允許透過合併多個通道來擴大規模。此功能可同時從多個樣本中分離血漿，從而提高通量並減少處理時間。流程的自動化進一步簡化了診斷工作流程，並有可能降低整體成本。

Broader Applications: Beyond Blood Plasma

更廣泛的應用：超越血漿

The platform technology underlying ExoArc has the potential to isolate bacteria or viruses from blood or other biofluids by adjusting the size cutoff. This opens up possibilities for rapid pathogen detection and improved diagnostics in infectious disease management.

ExoArc 的平台技術有可能透過調整大小截斷值從血液或其他生物液體中分離細菌或病毒。這為快速病原體檢測和改進傳染病管理診斷提供了可能性。

Funding and Innovation

資金和創新

ExoArc's development is supported by grants from the NTUitive Gap Fund. This funding initiative fosters innovation and entrepreneurship at NTU, transforming research into practical solutions that address societal challenges.

ExoArc 的開發得到了 NTUitive Gap 基金的資助。這項資助計畫促進南洋理工大學的創新和創業精神，將研究轉化為應對社會挑戰的實際解決方案。

Conclusion

結論

ExoArc represents a significant advancement in blood plasma isolation, offering high purity, rapid processing, and potential applications in a wide range of clinical settings. Its ability to replace centrifuges in the future could revolutionize the way blood samples are processed, leading to improved diagnostic accuracy and patient outcomes.

ExoArc 代表了血漿分離領域的重大進步，提供高純度、快速處理以及在廣泛臨床環境中的潛在應用。它未來取代離心機的能力可能會徹底改變血液樣本的處理方式，從而提高診斷準確性和患者治療結果。