芯片技术有望取代离心机以实现卓越的血浆分离

ExoArc 是一款创新设备，通过一步有效去除 99.9% 以上的血细胞和血小板，彻底改变了血浆分离，为生物标志物分析和纳米颗粒分离提供高纯度血浆。该技术为传统离心方法提供了更快、更精确的替代方案，能够快速临床诊断癌症等疾病，并改善糖尿病等慢性病的个性化医疗。

Can a Chip Replace the Centrifuge for Blood Plasma Isolation?

芯片可以替代离心机进行血浆分离吗？

The ExoArc device has emerged as a potential game-changer in blood plasma isolation, promising high-quality plasma with exceptional purity. Unlike traditional centrifuges, which rely on spinning blood samples to separate plasma, ExoArc utilizes a microfluidic chip to achieve a more precise and efficient separation process.

ExoArc 设备已成为血浆分离领域潜在的游戏规则改变者，有望提供具有卓越纯度的高质量血浆。与传统离心机依靠旋转血液样本来分离血浆不同，ExoArc 利用微流控芯片实现更精确、更高效的分离过程。

How Does ExoArc Achieve Such High Purity?

ExoArc 如何达到如此高的纯度？

ExoArc's microfluidic chip leverages unique flow dynamics within tiny channels to separate biological materials based on size. By precisely controlling the flow rates and channel dimensions, the chip effectively removes over 99.9% of blood cells and platelets in a single step. This high level of purity ensures minimal contamination from degraded cellular material, which can lead to inaccurate diagnostic tests.

ExoArc 的微流控芯片利用微小通道内独特的流动动力学来根据尺寸分离生物材料。通过精确控制流速和通道尺寸，该芯片可一步有效去除 99.9% 以上的血细胞和血小板。这种高纯度确保了降解细胞材料的污染最小化，这种污染可能导致诊断测试不准确。

Clinical Validation: Accurate Cancer Diagnosis

临床验证：准确的癌症诊断

In collaboration with clinicians from the National Cancer Center Singapore (NCCS) and other medical institutions, ExoArc's performance was clinically validated. The device successfully diagnosed non-small cell lung cancer with a sensitivity of 90% by analyzing the microRNA profile of blood plasma. This demonstrates ExoArc's potential for early and accurate cancer detection.

ExoArc 与新加坡国家癌症中心 (NCCS) 和其他医疗机构的临床医生合作，其性能得到了临床验证。该设备通过分析血浆的 microRNA 谱，成功诊断出非小细胞肺癌，灵敏度高达 90%。这证明了 ExoArc 在早期、准确的癌症检测方面的潜力。

Beyond Cancer: Applications in Diabetes Research

超越癌症：在糖尿病研究中的应用

ExoArc's versatility extends beyond cancer diagnosis. The team also demonstrated its utility in studying microRNA molecules from blood plasma samples of individuals with type 2 diabetes mellitus. By identifying 293 different microRNA molecules, the research suggests ExoArc's potential for isolating and identifying disease-related biomarkers in a wide range of conditions.

ExoArc 的多功能性超出了癌症诊断的范围。该团队还展示了其在研究 2 型糖尿病患者血浆样本中的 microRNA 分子方面的实用性。通过识别 293 种不同的 microRNA 分子，该研究表明 ExoArc 在多种条件下分离和识别疾病相关生物标志物的潜力。

Benefits for Patients and Clinicians

对患者和临床医生的好处

ExoArc offers several advantages over conventional centrifuges. Its automated and rapid isolation process significantly reduces waiting time for test results, alleviating patient anxiety. Additionally, the high-quality plasma obtained through ExoArc enables more accurate diagnostic tests, leading to improved patient care.

与传统离心机相比，ExoArc 具有多种优势。其自动化、快速的隔离过程显着减少了检测结果的等待时间，减轻了患者的焦虑。此外，通过 ExoArc 获得的高质量血浆可以实现更准确的诊断测试，从而改善患者护理。

Scaling Up for Clinical Implementation

扩大临床实施规模

ExoArc's modular design allows for scaling up by incorporating multiple channels. This feature enables simultaneous isolation of blood plasma from multiple samples, increasing throughput and reducing processing time. Automation of the process further streamlines the diagnostic workflow and potentially reduces overall costs.

ExoArc 的模块化设计允许通过合并多个通道来扩大规模。该功能可以同时从多个样本中分离血浆，从而提高通量并减少处理时间。该过程的自动化进一步简化了诊断工作流程，并有可能降低总体成本。

Broader Applications: Beyond Blood Plasma

更广泛的应用：超越血浆

The platform technology underlying ExoArc has the potential to isolate bacteria or viruses from blood or other biofluids by adjusting the size cutoff. This opens up possibilities for rapid pathogen detection and improved diagnostics in infectious disease management.

ExoArc 的平台技术有可能通过调整大小截断值从血液或其他生物液体中分离细菌或病毒。这为快速病原体检测和改进传染病管理诊断提供了可能性。

Funding and Innovation

资金和创新

ExoArc's development is supported by grants from the NTUitive Gap Fund. This funding initiative fosters innovation and entrepreneurship at NTU, transforming research into practical solutions that address societal challenges.

ExoArc 的开发得到了 NTUitive Gap 基金的资助。这项资助计划促进南洋理工大学的创新和创业精神，将研究转化为应对社会挑战的实际解决方案。

Conclusion

结论

ExoArc represents a significant advancement in blood plasma isolation, offering high purity, rapid processing, and potential applications in a wide range of clinical settings. Its ability to replace centrifuges in the future could revolutionize the way blood samples are processed, leading to improved diagnostic accuracy and patient outcomes.

ExoArc 代表了血浆分离领域的重大进步，提供高纯度、快速处理以及在广泛临床环境中的潜在应用。它未来取代离心机的能力可能会彻底改变血液样本的处理方式，从而提高诊断准确性和患者治疗结果。