突破性生物感測器顛覆慢性阻塞性肺病管理

倫德奎斯特研究所的研究團隊獲得了超過260 萬美元的四年資助，用於創建一種可穿戴生物感測器，該感測器可以持續分析汗液，以監測慢性阻塞性肺病患者的急性加重風險。該計畫由Harry Rossiter 博士領導，與加州理工學院合作，旨在透過汗液生物標記分析來識別病情加重的早期預警信號，這可能會徹底改變慢性阻塞性肺病的管理，並將可穿戴電子產品整合到慢性病照護中。

Pioneering Biosensor to Revolutionize COPD Management

開創性生物感測器徹底改變慢性阻塞性肺病 (COPD) 管理

A groundbreaking research team at The Lundquist Institute has secured a substantial four-year grant from the U.S. Army Medical Research Acquisition Activity, supported by the U.S. Department of Defense’s Peer Reviewed Medical Research Program, to develop a transformative wearable biosensor for chronic obstructive pulmonary disease (COPD). This groundbreaking technology aims to continuously monitor the risk of acute exacerbations, paving the way for real-time disease management and improved patient outcomes.

倫德奎斯特研究所的一個開創性研究團隊已從美國陸軍醫學研究採購活動獲得了一筆為期四年的巨額資助，該計畫得到了美國國防部同行評審醫學研究計劃的支持，旨在開發一種用於慢性阻塞性肺病的變革性穿戴式生物感測器。這項突破性技術旨在持續監測急性惡化的風險，為即時疾病管理和改善患者治療結果鋪路。

Collaborative Innovation for Patient Empowerment

為病患賦權的協作創新

The project, led by Harry Rossiter, PhD, a TLI investigator and professor of respiratory and critical care physiology and medicine at the David Geffen School of Medicine at the University of California, Los Angeles, is a testament to the power of collaboration. Joining forces with Wei Gao, PhD, a materials scientist and engineer at the California Institute of Technology (Caltech), the team is harnessing their expertise to create a wearable biosensor that will empower COPD patients with critical health insights.

該計畫由 TLI 研究員、加州大學洛杉磯分校大衛格芬醫學院呼吸和重症監護生理學和醫學教授 Harry Rossiter 博士領導，證明了合作的力量。該團隊與加州理工學院 (Caltech) 的材料科學家兼工程師 Wei Gau 博士聯手，利用他們的專業知識創建一種可穿戴生物感測器，為慢性阻塞性肺病 (COPD) 患者提供重要的健康見解。

Early Detection, Proactive Intervention

早期發現，主動幹預

COPD, a debilitating condition that affects millions worldwide, is characterized by chronic inflammation in the lungs that obstructs airflow. While there is currently no cure for COPD, early detection of acute exacerbations, or flares, is crucial for preventing serious health complications.

慢性阻塞性肺病是一種使人衰弱的疾病，影響著全球數百萬人，其特徵是肺部慢性發炎阻礙氣流。雖然目前慢性阻塞性肺病無法治愈，但早期發現急性加重或發作對於預防嚴重的健康併發症至關重要。

The wearable biosensor being developed by Rossiter and Gao will continuously analyze sweat for telltale signs of an impending flare. By identifying these early biomarkers, the sensor will provide real-time guidance on disease management, eliminating the need for frequent blood tests and enabling proactive interventions.

羅西特和高正在開發的可穿戴生物感測器將持續分析汗液，以發現即將爆發的跡象。透過識別這些早期生物標誌物，感測器將為疾病管理提供即時指導，消除頻繁血液檢測的需要並實現主動幹預。

Non-Invasive Monitoring for Improved Health

非侵入性監測改善健康

"The proposed sensor has the potential to revolutionize COPD management but also to impact healthcare by incorporating wearable electronics into chronic disease management," said Rossiter. "Our ultimate goal is to develop a wearable system to preempt [acute exacerbations], providing an early warning system to move treatment earlier in the exacerbation process and thereby reduce patient morbidity, mortality, hospitalization, and healthcare utilization."

羅西特說：“所提出的傳感器有可能徹底改變慢性阻塞性肺病的管理，而且還可以通過將可穿戴電子設備納入慢性病管理來影響醫療保健。” 「我們的最終目標是開發一種穿戴式系統來預防[急性惡化]，提供早期預警系統，以便在急性惡化過程中儘早進行治療，從而降低患者的發病率、死亡率、住院率和醫療保健利用率。

The biosensor, worn as a patch, will measure C-reactive protein levels in sweat, an inflammatory marker that can differentiate between mild and moderate flares. The grant will support the development of a more sophisticated sensor capable of measuring multiple molecules in sweat, enhancing its predictive power.

這種生物感測器作為貼片佩戴，將測量汗液中的 C 反應蛋白水平，這是一種發炎標記物，可以區分輕度和中度發炎。這筆贈款將支持開發一種更複雜的感測器，能夠測量汗液中的多個分子，從而增強其預測能力。

Transforming Healthcare through Wearable Technology

透過穿戴式科技改變醫療保健

"In partnership with Dr. Harry Rossiter and The Lundquist Institute, our team at Caltech is advancing medical technology with wearable biosensors," said Gao. "Our aim with this project is to transform chronic disease management and push healthcare towards continuous, non-invasive monitoring for better health."

「我們加州理工學院的團隊與 Harry Rossiter 博士和倫德奎斯特研究所合作，正在利用可穿戴生物感測器推進醫療技術，」高說。 “我們這個計畫的目標是改變慢性病管理，推動醫療保健走向持續、非侵入性監測，以改善健康狀況。”

The Lundquist Institute, a renowned biomedical research organization affiliated with the University of California, Los Angeles, is committed to developing innovative solutions for complex health challenges. Their collaboration with Caltech underscores the transformative potential of wearable technology in improving the lives of those living with chronic conditions.

倫德奎斯特研究所是隸屬於加州大學洛杉磯分校的著名生物醫學研究機構，致力於開發複雜健康挑戰的創新解決方案。他們與加州理工學院的合作強調了穿戴式科技在改善慢性病患者生活方面的變革潛力。

Empowering Patients, Improving Outcomes

賦予病患權力，改善結果

By empowering patients with real-time monitoring and proactive treatment strategies, the wearable biosensor developed by Rossiter and Gao has the potential to revolutionize COPD management. By reducing the risk of acute exacerbations, improving overall health outcomes, and reducing healthcare utilization, this groundbreaking technology promises to transform the lives of countless COPD patients.

Rossiter 和高開發的穿戴式生物感測器透過為患者提供即時監測和主動治療策略，有可能徹底改變慢性阻塞性肺病的管理。透過降低急性惡化的風險、改善整體健康結果並減少醫療保健利用率，這項突破性技術有望改變無數慢性阻塞性肺病患者的生活。